{
  "schemaVersion": "1.0.0",
  "curatedAt": "2026-10-10",
  "corpus": {
    "id": "psychdoc",
    "title": "PsychDoc · Depression evidence",
    "domain": "Clinical research",
    "question": "Which parts of a psilocybin depression result survive an assumed bias shift?",
    "summary": "Inspect a saved analysis, its population limits and the assumptions that change its interpretation.",
    "sourceVersion": "PsychDoc 3001296 · SYPRES 25.1.2 · packet 2026-10-10.1",
    "reviewStatus": "Curated demonstration · Stage B awaits independent scientific review",
    "scopeNote": "A replay of saved results from a mixed-population dataset. Trial-level source-input audit remains incomplete. This is evidence education, not treatment advice; neither the packet nor the slider establishes clinical benefit for an individual.",
    "sources": [
      {
        "id": "sypres-paper",
        "title": "A living systematic review, meta-analysis and open-data resource of randomized controlled trials of psilocybin treatment for symptoms of depression",
        "url": "https://doi.org/10.1038/s44220-026-00630-8",
        "year": 2026,
        "locator": "Public abstract; article Methods, Results and Supplement were not re-audited for this packet.",
        "kind": "Published meta-analysis"
      },
      {
        "id": "sypres-data",
        "title": "SYPRES depression-psiloctr, version 25.1.2",
        "url": "https://doi.org/10.5281/zenodo.17657950",
        "year": 2025,
        "locator": "Pinned data.csv; SHA-256 237b4a5601bd4de1b1c1b0e335e730677c2b09cd7a3ce2c893df623e9feba793. Trial inputs have not all been checked against reports.",
        "kind": "Versioned dataset"
      },
      {
        "id": "psychdoc-stage-b",
        "title": "PsychDoc Stage B saved sensitivity analysis",
        "url": "https://psychdoc.ai/#stress",
        "year": 2026,
        "locator": "Saved stability.json at PsychDoc commit 3001296325cb95d64fcca6e412eb10b48264144a: primary, mdd-trd and prediction interval; see downloadable provenance.",
        "kind": "Saved analysis · review pending"
      },
      {
        "id": "sypres-code",
        "title": "SYPRES analysis release 26.0.0",
        "url": "https://github.com/PennLINC/sypres-docs/tree/26.0.0",
        "year": 2026,
        "locator": "psilodep-meta-analysis.Rmd. Existing PsychDoc rerun receipt was inspected; the original R model was not rerun during this website build.",
        "kind": "Author analysis code"
      }
    ],
    "claims": [
      {
        "id": "psychdoc-primary",
        "text": "The saved primary analysis pools 12 trials: Hedges’ g −0.90, with a 95% confidence interval from −1.26 to −0.55.",
        "status": "Saved result · independent review pending",
        "sourceIds": [
          "sypres-data",
          "psychdoc-stage-b",
          "sypres-paper",
          "sypres-code"
        ],
        "caveat": "Negative values favour psilocybin. The dataset combines several clinical populations and controls; this is not an MDD-only effect, a durability estimate or a treatment recommendation.",
        "conditions": [
          {
            "label": "Endpoint",
            "value": "Standardized depression-score effect (Hedges’ g)"
          },
          {
            "label": "Population",
            "value": "Mixed trial populations; not MDD/TRD alone"
          },
          {
            "label": "Window",
            "value": "Primary windows: 14–49 days after final dose"
          },
          {
            "label": "Model",
            "value": "Saved REML / Hartung–Knapp primary analysis"
          }
        ]
      },
      {
        "id": "psychdoc-subgroup",
        "text": "For the five MDD or TRD trials alone, the saved estimate is −0.93; its 95% interval, −1.87 to 0.01, includes no effect.",
        "status": "Saved subgroup · independent review pending",
        "sourceIds": [
          "sypres-data",
          "psychdoc-stage-b"
        ],
        "caveat": "Two of the five trials are open-label waitlist comparisons. The subgroup and primary result reuse trials; they are not independent replications.",
        "conditions": [
          {
            "label": "Endpoint",
            "value": "Hedges’ g; same orientation as primary result"
          },
          {
            "label": "Population",
            "value": "MDD or treatment-resistant depression"
          },
          {
            "label": "Evidence subset",
            "value": "5 trials; 2 open-label waitlist comparisons"
          },
          {
            "label": "Interpretation",
            "value": "Uncertainty includes zero"
          }
        ]
      },
      {
        "id": "psychdoc-prediction",
        "text": "The saved primary model’s 95% prediction interval is wider: −1.73 to −0.08.",
        "status": "Saved prediction interval · review pending",
        "sourceIds": [
          "sypres-data",
          "psychdoc-stage-b"
        ],
        "caveat": "This model-conditional interval for a new comparable trial is not the confidence interval for the pooled mean. It crosses both illustrative benefit thresholds used in this demo.",
        "conditions": [
          {
            "label": "Endpoint",
            "value": "Hedges’ g in a new comparable trial"
          },
          {
            "label": "Interval type",
            "value": "95% prediction interval"
          },
          {
            "label": "Dependence",
            "value": "Same fitted primary analysis, not new evidence"
          },
          {
            "label": "Scope",
            "value": "Model assumptions and comparability still apply"
          }
        ]
      }
    ],
    "lineage": [
      {
        "id": "psychdoc-records",
        "label": "Pinned SYPRES data release",
        "sourceIds": [
          "sypres-data"
        ],
        "status": "Dataset identity pinned; source-input audit incomplete"
      },
      {
        "id": "psychdoc-reproduction",
        "label": "Author code → saved PsychDoc analysis",
        "sourceIds": [
          "sypres-code",
          "psychdoc-stage-b"
        ],
        "status": "Existing reproduction inspected; no new refit in this demo"
      },
      {
        "id": "psychdoc-shared",
        "label": "Primary, subgroup and prediction outputs reuse evidence",
        "sourceIds": [
          "sypres-data",
          "psychdoc-stage-b"
        ],
        "status": "Do not count these outputs as independent studies"
      }
    ],
    "capabilities": [
      "Source-linked claims",
      "Explicit population and endpoint limits",
      "Saved additive-bias replay"
    ]
  },
  "analysis": {
    "corpusId": "psychdoc",
    "label": "Replay of a saved analysis · assumed additive bias",
    "sourceUrl": "https://psychdoc.ai/#stress",
    "sourceVersion": "PsychDoc 3001296 · stability.json SHA-256 7289ec7d89f6df0061d2aa7508f58c4d46c37a611a5838162470596ff1e1ace1",
    "reviewStatus": "Stage B awaits independent scientific review",
    "estimate": -0.9030829073153204,
    "lower": -1.256109404142053,
    "upper": -0.5500564104885878,
    "thresholds": [
      -0.24,
      -0.5
    ],
    "biasRange": [
      0,
      0.6
    ],
    "unit": "Hedges’ g",
    "direction": "Negative values favour psilocybin",
    "intervalLabel": "95% confidence interval",
    "note": "Add the same assumed positive shift to the saved estimate and both confidence bounds. Interval width stays fixed. The shift is imposed, not estimated; this is a replay, not a refit or a probability of truth. The two thresholds are inherited illustrative choices, not patient-specific cutoffs. It does not apply to the materials packet."
  }
}